Efficacy Of Glucosamine And Chondroitin Sulfate May Depend On Level Of Osteoarthritis Pain Part 8

* The Arthritis Research and Clinical Centers, Wichita, KS; Frederick Wolfe, M.D.

* University of Nebraska Medical Center, Omaha, NE; James O'Dell, M.D.

* Hospital all for Joint Diseases, New York, NY; Clifton Bingham, III, M.D.

* Case Western Reserve University, Cleveland, OH; Michele Hooper, M.D.

* University of Pennsylvania, Philadelphia, PA; H. Ralph Schumacher, Jr., M.D.

* University of Pittsburgh, Pittsburgh, PA; Chester Oddis, M.D.

* Presbyterian Hospital of Dallas, Dallas, TX; John J. Cush, M.D.

* University of Utah, Salt Lake City, UT; Christopher G. Jackson, M.D.

* Virginia Mason Medical Center, Seattle, WA; Jerry Molitor, M.D.

KEY RESULTS What be the switch grades of the be taught? Researchers found that: * Participants taking the carbonated dictate, celecoxib, tested statistically obligatory torment relief versus placebo--about 70 percent of those taking celecoxib have a 20 percent or greater decay contained with pain versus going by for 60 percent for placebo.

* Overall, implicit were no significant difference linking the other coverage tested and placebo.

* For a subset of participant beside moderate-to-severe pain, glucosamine joined with chondroitin sulfate provide statistically significant pain relief dangle out to placebo--about 79 percent had a 20 percent or greater reduction commotion versus about 54 percent for placebo. According to the researchers, because of the mini vastness of this subgroup these findings should be considered preliminary and inevitability to be confirmed in further study.

* For participants in the balmy pain subset, glucosamine and chondroitin sulfate both or alone execute not deliver statistically significant pain relief.

How several nation slice in the study and who were they?

A inclusive of 1,583 people participated in the study. People age 40 or elder with knees pain and usual x-ray support of osteoarthritis were eligible to participate. Participants could not relish previously owned glucosamine for 3 months and chondroitin sulfate for 6 months prior to entering the study. Participants were about 59 years of age, on standard, and nearly two-thirds of participants were women. Of the 1,583 study participants 78 percent (1,229) were in the mild pain subgroup and 22 percent (354) were in the moderate-to-severe pain subgroup.

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